Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications

Lasso peptides are a unique family of natural products whose structures feature a specific threaded fold, which confers these peptides the resistance to thermal and proteolytic degradation. This stability gives lasso peptides excellent pharmacokinetic properties, which together with their diverse re...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Tan, Ma, Xiaojie, Yu, Jiahui, Yang, Wensheng, Wang, Guiyang, Wang, Zhengdong, Ge, Yuanjie, Song, Juan, Han, Hua, Zhang, Wen, Yang, Donghui, Liu, Xuehui, Ma, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480316/
https://www.ncbi.nlm.nih.gov/pubmed/34603665
http://dx.doi.org/10.1039/d1sc02695j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480316/
https://www.ncbi.nlm.nih.gov/pubmed/34603665
http://dx.doi.org/10.1039/d1sc02695j

Ejemplares similares