Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications

Lasso peptides are a unique family of natural products whose structures feature a specific threaded fold, which confers these peptides the resistance to thermal and proteolytic degradation. This stability gives lasso peptides excellent pharmacokinetic properties, which together with their diverse re...

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Detalles Bibliográficos
Autores principales: Liu, Tan, Ma, Xiaojie, Yu, Jiahui, Yang, Wensheng, Wang, Guiyang, Wang, Zhengdong, Ge, Yuanjie, Song, Juan, Han, Hua, Zhang, Wen, Yang, Donghui, Liu, Xuehui, Ma, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480316/
https://www.ncbi.nlm.nih.gov/pubmed/34603665
http://dx.doi.org/10.1039/d1sc02695j

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