Chemoenzymatic glycan-selective remodeling of a therapeutic lysosomal enzyme with high-affinity M6P-glycan ligands. Enzyme substrate specificity is the name of the game

Functionalization of therapeutic lysosomal enzymes with mannose-6-phosphate (M6P) glycan ligands represents a major strategy for enhancing the cation-independent M6P receptor (CI-MPR)-mediated cellular uptake, thus improving the overall therapeutic efficacy of the enzymes. However, the minimal high-...

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Detalles Bibliográficos
Autores principales: Zhang, Xiao, Liu, Huiying, Meena, Naresh, Li, Chao, Zong, Guanghui, Raben, Nina, Puertollano, Rosa, Wang, Lai-Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480326/
https://www.ncbi.nlm.nih.gov/pubmed/34603676
http://dx.doi.org/10.1039/d1sc03188k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480326/
https://www.ncbi.nlm.nih.gov/pubmed/34603676
http://dx.doi.org/10.1039/d1sc03188k

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