Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group

Histone deacetylase 6 (HDAC6) is an established drug target for cancer treatment. Inhibitors of HDAC6 based on a hydroxamic acid zinc binding group (ZBG) are often associated with undesirable side effects. Herein, we describe the identification of HDAC6 inhibitors based on a completely new 3-hydroxy...

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Detalles Bibliográficos
Autores principales: Linciano, Pasquale, Pinzi, Luca, Belluti, Silvia, Chianese, Ugo, Benedetti, Rosaria, Moi, Davide, Altucci, Lucia, Franchini, Silvia, Imbriano, Carol, Sorbi, Claudia, Rastelli, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480759/
https://www.ncbi.nlm.nih.gov/pubmed/34583596
http://dx.doi.org/10.1080/14756366.2021.1981306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480759/
https://www.ncbi.nlm.nih.gov/pubmed/34583596
http://dx.doi.org/10.1080/14756366.2021.1981306

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