Efficient Dimerization Disruption of Leishmania infantum Trypanothione Reductase by Triazole-phenyl-thiazoles

[Image: see text] Inhibition of Leishmania infantum trypanothione disulfide reductase (LiTryR) by disruption of its homodimeric interface has proved to be an alternative and unexploited strategy in the search for novel antileishmanial agents. Proof of concept was first obtained by peptides and pepti...

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Detalles Bibliográficos
Autores principales: Revuelto, Alejandro, de Lucio, Héctor, García-Soriano, Juan Carlos, Sánchez-Murcia, Pedro A., Gago, Federico, Jiménez-Ruiz, Antonio, Camarasa, María-José, Velázquez, Sonsoles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480782/
https://www.ncbi.nlm.nih.gov/pubmed/33945281
http://dx.doi.org/10.1021/acs.jmedchem.1c00206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480782/
https://www.ncbi.nlm.nih.gov/pubmed/33945281
http://dx.doi.org/10.1021/acs.jmedchem.1c00206

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