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Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression

Alternative splicing of the gene MAPT produces several isoforms of tau protein. Overexpression of these isoforms is characteristic of tauopathies, which are currently untreatable neurodegenerative diseases. Though non-canonical functions of tau have drawn interest, the role of tau isoforms in these...

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Detalles Bibliográficos
Autores principales: Grundman, Jennifer, Spencer, Brian, Sarsoza, Floyd, Rissman, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480850/
https://www.ncbi.nlm.nih.gov/pubmed/34587152
http://dx.doi.org/10.1371/journal.pone.0251611