Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure

Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been attributed to antigenic variation of its putative outer-membrane protein TprK. In TprK, amino acid diversity is confined to seven variable (V) regions, and generation of sequence diversity within the V regions occurs via...

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Detalles Bibliográficos
Autores principales: Lin, Michelle J., Haynes, Austin M., Addetia, Amin, Lieberman, Nicole A. P., Phung, Quynh, Xie, Hong, Nguyen, Tien V., Molini, Barbara J., Lukehart, Sheila A., Giacani, Lorenzo, Greninger, Alexander L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480903/
https://www.ncbi.nlm.nih.gov/pubmed/34492041
http://dx.doi.org/10.1371/journal.pntd.0009753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480903/
https://www.ncbi.nlm.nih.gov/pubmed/34492041
http://dx.doi.org/10.1371/journal.pntd.0009753

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