Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system

To study how cancer cells can withstand fluid shear stress (SS), we isolated SS-resistant breast and lung cancer cells using a microfluidic circulatory system. These SS-resistant cells showed higher abilities to form clusters, survive in circulation, and metastasize in mice. These SS-resistant cells...

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Detalles Bibliográficos
Autores principales: Li, Koukou, Wu, Renfei, Zhou, Muya, Tong, Haibo, Luo, Kathy Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480931/
https://www.ncbi.nlm.nih.gov/pubmed/34586853
http://dx.doi.org/10.1126/sciadv.abg7265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480931/
https://www.ncbi.nlm.nih.gov/pubmed/34586853
http://dx.doi.org/10.1126/sciadv.abg7265

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