Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain (RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in the RBD are present in SARS-CoV-2 variants of concern that have emerged independently worldwide. For example, the B.1.1.7...

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Detalles Bibliográficos
Autores principales: Barton, Michael I, MacGowan, Stuart A, Kutuzov, Mikhail A, Dushek, Omer, Barton, Geoffrey John, van der Merwe, P Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480977/
https://www.ncbi.nlm.nih.gov/pubmed/34435953
http://dx.doi.org/10.7554/eLife.70658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480977/
https://www.ncbi.nlm.nih.gov/pubmed/34435953
http://dx.doi.org/10.7554/eLife.70658

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