APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population

In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pat...

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Detalles Bibliográficos
Autores principales: Garcia, Angela R, Finch, Caleb, Gatz, Margaret, Kraft, Thomas, Eid Rodriguez, Daniel, Cummings, Daniel, Charifson, Mia, Buetow, Kenneth, Beheim, Bret A, Allayee, Hooman, Thomas, Gregory S, Stieglitz, Jonathan, Gurven, Michael D, Kaplan, Hillard, Trumble, Benjamin C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480980/
https://www.ncbi.nlm.nih.gov/pubmed/34586066
http://dx.doi.org/10.7554/eLife.68231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480980/
https://www.ncbi.nlm.nih.gov/pubmed/34586066
http://dx.doi.org/10.7554/eLife.68231

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