Placental endocrine function shapes cerebellar development and social behavior

Compromised placental function or premature loss has been linked to diverse neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a progesterone-derived GABA-A receptor (GABA(A)R) modulator, reduction alters neurodevelopment in a sex-linked manner. A new conditional mouse...

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Detalles Bibliográficos
Autores principales: Vacher, Claire-Marie, Lacaille, Helene, O’Reilly, Jiaqi J., Salzbank, Jacquelyn, Bakalar, Dana, Sebaoui, Sonia, Liere, Philippe, Clarkson-Paredes, Cheryl, Sasaki, Toru, Sathyanesan, Aaron, Kratimenos, Panagiotis, Ellegood, Jacob, Lerch, Jason P., Imamura, Yuka, Popratiloff, Anastas, Hashimoto-Torii, Kazue, Gallo, Vittorio, Schumacher, Michael, Penn, Anna A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481124/
https://www.ncbi.nlm.nih.gov/pubmed/34400844
http://dx.doi.org/10.1038/s41593-021-00896-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481124/
https://www.ncbi.nlm.nih.gov/pubmed/34400844
http://dx.doi.org/10.1038/s41593-021-00896-4

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