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Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9

Despite four decades of research to support the association between DNA methylation and gene expression, the causality of this relationship remains unresolved. Here, we reaffirm that experimental confounds preclude resolution of this question with existing strategies, including recently developed CR...

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Detalles Bibliográficos
Autores principales: Sapozhnikov, Daniel M., Szyf, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481236/
https://www.ncbi.nlm.nih.gov/pubmed/34588447
http://dx.doi.org/10.1038/s41467-021-25991-9