Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction

Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells increases inflammatory osteolysis and decreases bone formation, thereby predisposing patients to pathological fracture and cancer growth. Alteration of osteoblast function induces skeletal diseases due to the disrupti...

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Detalles Bibliográficos
Autores principales: Back, Jungho, Nguyen, Minh Nam, Li, Lu, Lee, Saelim, Lee, Inkyu, Chen, Fancheng, Gillinov, Lauren, Chung, Yeon-Ho, Alder, Kareme D., Kwon, Hyuk-Kwon, Yu, Kristin E., Dussik, Christopher M., Hao, Zichen, Flores, Michael J., Kim, Yoseph, Ibe, Izuchukwu K., Munger, Alana M., Seo, Sung Wook, Lee, Francis Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481290/
https://www.ncbi.nlm.nih.gov/pubmed/34588427
http://dx.doi.org/10.1038/s41413-021-00158-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481290/
https://www.ncbi.nlm.nih.gov/pubmed/34588427
http://dx.doi.org/10.1038/s41413-021-00158-w

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