The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages

NLRP3 inflammasome is a vital player in macrophages pyroptosis, which is a type of proinflammatory cell-death and takes part in the pathogenesis of atherosclerosis. In this study, we used apoE(−/−) mice and ox-LDL induced THP-1 derived macrophages to explore the mechanisms of MCC950, a selective NLR...

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Detalles Bibliográficos
Autores principales: Zeng, Wenyun, Wu, Danbin, Sun, Yingxin, Suo, Yanrong, Yu, Qun, Zeng, Miao, Gao, Qing, Yu, Bin, Jiang, Xijuan, Wang, Yijing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481539/
https://www.ncbi.nlm.nih.gov/pubmed/34588488
http://dx.doi.org/10.1038/s41598-021-98437-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481539/
https://www.ncbi.nlm.nih.gov/pubmed/34588488
http://dx.doi.org/10.1038/s41598-021-98437-3

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