SPOP mutation induces DNA methylation via stabilizing GLP/G9a

Mutations in SPOP E3 ligase gene are reportedly associated with genome-wide DNA hypermethylation in prostate cancer (PCa) although the underlying mechanisms remain elusive. Here, we demonstrate that SPOP binds and promotes polyubiquitination and degradation of histone methyltransferase and DNMT inte...

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Detalles Bibliográficos
Autores principales: Zhang, Jianong, Gao, Kun, Xie, Hongyan, Wang, Dejie, Zhang, Pingzhao, Wei, Ting, Yan, Yuqian, Pan, Yunqian, Ye, Wenbin, Chen, Huifen, Shi, Qing, Li, Yao, Zhao, Shi-min, Hou, Xiaonan, Weroha, Saravut J., Wang, Yuzhuo, Zhang, Jun, Karnes, R. Jeffrey, He, Housheng Hansen, Wang, Liguo, Wang, Chenji, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481544/
https://www.ncbi.nlm.nih.gov/pubmed/34588438
http://dx.doi.org/10.1038/s41467-021-25951-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481544/
https://www.ncbi.nlm.nih.gov/pubmed/34588438
http://dx.doi.org/10.1038/s41467-021-25951-3

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