SPOP mutation induces DNA methylation via stabilizing GLP/G9a

Mutations in SPOP E3 ligase gene are reportedly associated with genome-wide DNA hypermethylation in prostate cancer (PCa) although the underlying mechanisms remain elusive. Here, we demonstrate that SPOP binds and promotes polyubiquitination and degradation of histone methyltransferase and DNMT inte...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Jianong, Gao, Kun, Xie, Hongyan, Wang, Dejie, Zhang, Pingzhao, Wei, Ting, Yan, Yuqian, Pan, Yunqian, Ye, Wenbin, Chen, Huifen, Shi, Qing, Li, Yao, Zhao, Shi-min, Hou, Xiaonan, Weroha, Saravut J., Wang, Yuzhuo, Zhang, Jun, Karnes, R. Jeffrey, He, Housheng Hansen, Wang, Liguo, Wang, Chenji, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481544/
https://www.ncbi.nlm.nih.gov/pubmed/34588438
http://dx.doi.org/10.1038/s41467-021-25951-3

Ejemplares similares

Ejemplares similares