Molecular Dynamics Simulations Identify Tractable Lead-like Phenyl-Piperazine Scaffolds as eIF4A1 ATP-competitive Inhibitors

[Image: see text] eIF4A1 is an ATP-dependent RNA helicase whose overexpression and activity have been tightly linked to oncogenesis in a number of malignancies. An understanding of the complex kinetics and conformational changes of this translational enzyme is necessary to map out all targetable bin...

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Detalles Bibliográficos
Autores principales: Essegian, Derek J., Cunningham, Tyler A., Zerio, Christopher J., Chapman, Eli, Schatz, Jonathan, Schürer, Stephan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482399/
https://www.ncbi.nlm.nih.gov/pubmed/34604625
http://dx.doi.org/10.1021/acsomega.1c02805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482399/
https://www.ncbi.nlm.nih.gov/pubmed/34604625
http://dx.doi.org/10.1021/acsomega.1c02805

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