The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy

Accumulation of α-synuclein is a main underlying pathological feature of Parkinson’s disease and α-synucleinopathies, for which lowering expression of the α-synuclein gene (SNCA) is a potential therapeutic avenue. Using a cell-based luciferase reporter of SNCA expression we performed a quantitative...

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Detalles Bibliográficos
Autores principales: Gandelman, Mandi, Dansithong, Warunee, Kales, Stephen C., Paul, Sharan, Maag, Gentrie, Aoyama, Erika, Zakharov, Alexey, Rai, Ganesha, Dexheimer, Thomas, Whitehill, Brooke M., Sun, Hongmao, Jadhav, Ajit, Simeonov, Anton, Henderson, Mark J., Huynh, Duong P., Pulst, Stefan M., Scoles, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482485/
https://www.ncbi.nlm.nih.gov/pubmed/34520759
http://dx.doi.org/10.1016/j.jbc.2021.101191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482485/
https://www.ncbi.nlm.nih.gov/pubmed/34520759
http://dx.doi.org/10.1016/j.jbc.2021.101191

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