PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance

BACKGROUND: Kinases play critical role in clear-cell renal cell carcinoma (ccRCC). We aim to exploit novel kinase that is both protumorigenic and drugable in ccRCC. METHODS: Reproduction of public datasets with validation using microarray was performed to identify candidate gene. Functionality was s...

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Detalles Bibliográficos
Autores principales: Feng, Chenchen, Li, Yuqing, Li, Kunping, Lyu, Yinfeng, Zhu, Wenhui, Jiang, Haowen, Wen, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482632/
https://www.ncbi.nlm.nih.gov/pubmed/34593007
http://dx.doi.org/10.1186/s13046-021-02103-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482632/
https://www.ncbi.nlm.nih.gov/pubmed/34593007
http://dx.doi.org/10.1186/s13046-021-02103-5

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