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PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance

BACKGROUND: Kinases play critical role in clear-cell renal cell carcinoma (ccRCC). We aim to exploit novel kinase that is both protumorigenic and drugable in ccRCC. METHODS: Reproduction of public datasets with validation using microarray was performed to identify candidate gene. Functionality was s...

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Detalles Bibliográficos
Autores principales:	Feng, Chenchen, Li, Yuqing, Li, Kunping, Lyu, Yinfeng, Zhu, Wenhui, Jiang, Haowen, Wen, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482632/ https://www.ncbi.nlm.nih.gov/pubmed/34593007 http://dx.doi.org/10.1186/s13046-021-02103-5

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