DNA aptamer raised against receptor for advanced glycation end products suppresses renal tubular damage and improves insulin resistance in diabetic mice

OBJECTIVE: Interaction of advanced glycation end products (AGEs) with the receptor RAGE plays a role in diabetic nephropathy. However, effects of RAGE-aptamer on tubular damage remain unknown. We examined whether RAGE-aptamer inhibited tubular damage in KKAy/Ta mice, obese type 2 diabetic mice with...

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Detalles Bibliográficos
Autores principales: Sotokawauchi, Ami, Matsui, Takanori, Higashimoto, Yuichiro, Nishino, Yuri, Koga, Yoshinori, Yagi, Minoru, Yamagishi, Sho-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482725/
https://www.ncbi.nlm.nih.gov/pubmed/33535822
http://dx.doi.org/10.1177/1479164121990533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482725/
https://www.ncbi.nlm.nih.gov/pubmed/33535822
http://dx.doi.org/10.1177/1479164121990533

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