MFN2 Deficiency Impairs Mitochondrial Transport and Downregulates Motor Protein Expression in Human Spinal Motor Neurons

Charcot-Marie-Tooth (CMT) disease is one of the most common genetically inherited neurological disorders and CMT type 2A (CMT 2A) is caused by dominant mutations in the mitofusin-2 (MFN2) gene. MFN2 is located in the outer mitochondrial membrane and is a mediator of mitochondrial fusion, with an ess...

Descripción completa

Detalles Bibliográficos
Autores principales: Mou, Yongchao, Dein, Joshua, Chen, Zhenyu, Jagdale, Mrunali, Li, Xue-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482798/
https://www.ncbi.nlm.nih.gov/pubmed/34602978
http://dx.doi.org/10.3389/fnmol.2021.727552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482798/
https://www.ncbi.nlm.nih.gov/pubmed/34602978
http://dx.doi.org/10.3389/fnmol.2021.727552

Ejemplares similares