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MFN2 Deficiency Impairs Mitochondrial Transport and Downregulates Motor Protein Expression in Human Spinal Motor Neurons

Charcot-Marie-Tooth (CMT) disease is one of the most common genetically inherited neurological disorders and CMT type 2A (CMT 2A) is caused by dominant mutations in the mitofusin-2 (MFN2) gene. MFN2 is located in the outer mitochondrial membrane and is a mediator of mitochondrial fusion, with an ess...

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Detalles Bibliográficos
Autores principales:	Mou, Yongchao, Dein, Joshua, Chen, Zhenyu, Jagdale, Mrunali, Li, Xue-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482798/ https://www.ncbi.nlm.nih.gov/pubmed/34602978 http://dx.doi.org/10.3389/fnmol.2021.727552

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