Downregulation of RAB7 and Caveolin-1 increases MMP-2 activity in renal tubular epithelial cells under hypoxic conditions

Tubulointerstitial fibrosis leads to tubular basement membrane thickening and accumulation of interstitial extracellular matrix (ECM). Matrix metallopeptidase-2 (MMP-2) is involved in the breakdown of ECM. Chronic hypoxia often occurs in the kidney tissues of patients with chronic kidney disease. Ou...

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Detalles Bibliográficos
Autores principales: Yu, Wenmin, Ke, Xiumei, Li, Meiren, Ye, Ping, Peng, Jing, Li, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483063/
https://www.ncbi.nlm.nih.gov/pubmed/34676302
http://dx.doi.org/10.1515/med-2021-0341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483063/
https://www.ncbi.nlm.nih.gov/pubmed/34676302
http://dx.doi.org/10.1515/med-2021-0341

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