Radiotherapy is associated with a deletion signature that contributes to poor outcomes in cancer patients

Ionizing radiation causes DNA damage and is a mainstay for cancer treatment, but we have limited understanding of its genomic impact. We analyzed mutational spectra following radiotherapy in 190 paired primary and recurrent gliomas from the Glioma Longitudinal Analysis (GLASS) Consortium and 3,693 p...

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Detalles Bibliográficos
Autores principales: Kocakavuk, Emre, Anderson, Kevin J., Varn, Frederick S., Johnson, Kevin C., Amin, Samirkumar B., Sulman, Erik. P., Lolkema, Martijn P., Barthel, Floris P., Verhaak, Roel G.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483261/
https://www.ncbi.nlm.nih.gov/pubmed/34045764
http://dx.doi.org/10.1038/s41588-021-00874-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483261/
https://www.ncbi.nlm.nih.gov/pubmed/34045764
http://dx.doi.org/10.1038/s41588-021-00874-3

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