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Radiotherapy is associated with a deletion signature that contributes to poor outcomes in cancer patients
Ionizing radiation causes DNA damage and is a mainstay for cancer treatment, but we have limited understanding of its genomic impact. We analyzed mutational spectra following radiotherapy in 190 paired primary and recurrent gliomas from the Glioma Longitudinal Analysis (GLASS) Consortium and 3,693 p...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483261/ https://www.ncbi.nlm.nih.gov/pubmed/34045764 http://dx.doi.org/10.1038/s41588-021-00874-3 |