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Protective CD4(+) Th1 cell-mediated immunity is reliant upon execution of effector function prior to the establishment of the pathogen niche

Intracellular infection with the parasite Leishmania major features a state of concomitant immunity in which CD4(+) T helper 1 (Th1) cell-mediated immunity against reinfection coincides with a chronic but sub-clinical primary infection. In this setting, the rapidity of the Th1 response at a secondar...

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Detalles Bibliográficos
Autores principales: Hohman, Leah S., Mou, Zhirong, Carneiro, Matheus B., Ferland, Gabriel, Kratofil, Rachel M., Kubes, Paul, Uzonna, Jude E., Peters, Nathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483310/
https://www.ncbi.nlm.nih.gov/pubmed/34543348
http://dx.doi.org/10.1371/journal.ppat.1009944