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Local topology and bifurcation hot-spots in proteins with SARS-CoV-2 spike protein as an example
Novel topological methods are introduced to protein research. The aim is to identify hot-spot sites where a bifurcation can alter the local topology of the protein backbone. Since the shape of a protein is intimately related to its biological function, a substitution that causes a bifurcation should...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483365/ https://www.ncbi.nlm.nih.gov/pubmed/34591922 http://dx.doi.org/10.1371/journal.pone.0257886 |