The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection

Topoisomerases are essential for the replication of herpesviruses but the mechanisms by which the viruses hijack the cellular enzymes are largely unknown. We found that topoisomerase-II (TOP2) is a substrate of the Epstein-Barr virus (EBV) ubiquitin deconjugase BPLF1. BPLF1 co-immunoprecipitated and...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jinlin, Nagy, Noemi, Liu, Jiangnan, Gupta, Soham, Frisan, Teresa, Hennig, Thomas, Cameron, Donald P., Baranello, Laura, Masucci, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483405/
https://www.ncbi.nlm.nih.gov/pubmed/34543352
http://dx.doi.org/10.1371/journal.ppat.1009954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483405/
https://www.ncbi.nlm.nih.gov/pubmed/34543352
http://dx.doi.org/10.1371/journal.ppat.1009954

Ejemplares similares