Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Functional delivery of mRNA has high clinical potential. Previous studies established that mRNAs can be delivered to cells in vitro and in vivo via RNA-loaded lipid nanoparticles (LNPs). Here we describe an alternative approach using exosomes, the only biologically normal nanovesicle. In contrast to...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsai, Shang Jui, Atai, Nadia A., Cacciottolo, Mafalda, Nice, Justin, Salehi, Arjang, Guo, Chenxu, Sedgwick, Alanna, Kanagavelu, Saravana, Gould, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483990/
https://www.ncbi.nlm.nih.gov/pubmed/34600888
http://dx.doi.org/10.1016/j.jbc.2021.101266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483990/
https://www.ncbi.nlm.nih.gov/pubmed/34600888
http://dx.doi.org/10.1016/j.jbc.2021.101266

Ejemplares similares