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Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Functional delivery of mRNA has high clinical potential. Previous studies established that mRNAs can be delivered to cells in vitro and in vivo via RNA-loaded lipid nanoparticles (LNPs). Here we describe an alternative approach using exosomes, the only biologically normal nanovesicle. In contrast to...

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Detalles Bibliográficos
Autores principales:	Tsai, Shang Jui, Atai, Nadia A., Cacciottolo, Mafalda, Nice, Justin, Salehi, Arjang, Guo, Chenxu, Sedgwick, Alanna, Kanagavelu, Saravana, Gould, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483990/ https://www.ncbi.nlm.nih.gov/pubmed/34600888 http://dx.doi.org/10.1016/j.jbc.2021.101266

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