Pharmacokinetics and safety of niraparib in patients with moderate hepatic impairment

PURPOSE: The purpose of this study is to characterize niraparib pharmacokinetics (PK) and safety in patients with normal hepatic function (NHF) versus moderate hepatic impairment (MHI). METHODS: Patients with advanced solid tumors were stratified by NHF or MHI (National Cancer Institute-Organ Dysfun...

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Detalles Bibliográficos
Autores principales: Akce, Mehmet, El-Khoueiry, Anthony, Piha-Paul, Sarina A., Bacque, Emeline, Pan, Peng, Zhang, Zhi-Yi, Ewesuedo, Reginald, Gupta, Divya, Tang, Yongqiang, Milton, Ashley, Zajic, Stefan, Judson, Patricia L., O’Bryant, Cindy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484145/
https://www.ncbi.nlm.nih.gov/pubmed/34324028
http://dx.doi.org/10.1007/s00280-021-04329-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484145/
https://www.ncbi.nlm.nih.gov/pubmed/34324028
http://dx.doi.org/10.1007/s00280-021-04329-8

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