Defined d-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease

In Myotonic Dystrophy type 1 (DM1), a non-coding CTG repeats rare expansion disease; toxic double-stranded RNA hairpins sequester the RNA-binding proteins Muscleblind-like 1 and 2 (MBNL1 and 2) and trigger other DM1-related pathogenesis pathway defects. In this paper, we characterize four d-amino ac...

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Detalles Bibliográficos
Autores principales: Rapisarda, Anna, Bargiela, Ariadna, Llamusi, Beatriz, Pont, Isabel, Estrada-Tejedor, Roger, Garcia-España, Enrique, Artero, Ruben, Perez-Alonso, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484449/
https://www.ncbi.nlm.nih.gov/pubmed/34593893
http://dx.doi.org/10.1038/s41598-021-98866-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484449/
https://www.ncbi.nlm.nih.gov/pubmed/34593893
http://dx.doi.org/10.1038/s41598-021-98866-0

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