Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing

A major class of bispecific antibodies (BsAbs) utilizes heterodimeric Fc to produce the native immunoglobulin G (IgG) structure. Because appropriate pairing of heavy and light chains is required, the design of BsAbs produced through recombination or reassembly of two separately-expressed antigen-bin...

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Detalles Bibliográficos
Autores principales: Akiba, Hiroki, Ise, Tomoko, Nagata, Satoshi, Kamada, Haruhiko, Ohno, Hiroaki, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484483/
https://www.ncbi.nlm.nih.gov/pubmed/34593913
http://dx.doi.org/10.1038/s41598-021-98855-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484483/
https://www.ncbi.nlm.nih.gov/pubmed/34593913
http://dx.doi.org/10.1038/s41598-021-98855-3

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