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Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing
A major class of bispecific antibodies (BsAbs) utilizes heterodimeric Fc to produce the native immunoglobulin G (IgG) structure. Because appropriate pairing of heavy and light chains is required, the design of BsAbs produced through recombination or reassembly of two separately-expressed antigen-bin...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484483/ https://www.ncbi.nlm.nih.gov/pubmed/34593913 http://dx.doi.org/10.1038/s41598-021-98855-3 |