Cargando…
Targeting the CD146/Galectin-9 axis protects the integrity of the blood–brain barrier in experimental cerebral malaria
Cerebral malaria (CM) is a life-threatening diffuse encephalopathy caused by Plasmodium falciparum, in which the destruction of the blood–brain barrier (BBB) is the main cause of death. However, increasing evidence has shown that antimalarial drugs, the current treatment for CM, do little to protect...
Autores principales: | Duan, Hongxia, Zhao, Shuai, Xiang, Jianquan, Ju, Chenhui, Chen, Xuehui, Gramaglia, Irene, Yan, Xiyun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484550/ https://www.ncbi.nlm.nih.gov/pubmed/33203936 http://dx.doi.org/10.1038/s41423-020-00582-8 |
Ejemplares similares
-
Soluble CD146, a cerebrospinal fluid marker for neuroinflammation, promotes blood-brain barrier dysfunction
por: Wang, Daji, et al.
Publicado: (2020) -
CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity
por: Duan, Hongxia, et al.
Publicado: (2022) -
Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146
por: Chen, Xuehui, et al.
Publicado: (2021) -
A subpopulation of CD146(+) macrophages enhances antitumor immunity by activating the NLRP3 inflammasome
por: Jing, Lin, et al.
Publicado: (2023) -
Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS
por: Duan, Hongxia, et al.
Publicado: (2013)