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Genetic drift from the out-of-Africa bottleneck leads to biased estimation of genetic architecture and selection
Most complex traits evolved in the ancestors of all modern humans and have been under negative or balancing selection to maintain the distribution of phenotypes observed today. Yet all large studies mapping genomes to complex traits occur in populations that have experienced the Out-of-Africa bottle...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484570/ https://www.ncbi.nlm.nih.gov/pubmed/33846580 http://dx.doi.org/10.1038/s41431-021-00873-2 |