Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease

The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are important nitrogen donors for synthesis of glutamate, the main excitatory neurotransmitter in the brain. The glutamate carbon skeleton originates from the tricarboxylic acid (TCA) cycle intermediate α-ketoglutarate, while the...

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Detalles Bibliográficos
Autores principales: Salcedo, Claudia, Andersen, Jens V., Vinten, Kasper Tore, Pinborg, Lars H., Waagepetersen, Helle S., Freude, Kristine K., Aldana, Blanca I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484639/
https://www.ncbi.nlm.nih.gov/pubmed/34603012
http://dx.doi.org/10.3389/fnagi.2021.736580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484639/
https://www.ncbi.nlm.nih.gov/pubmed/34603012
http://dx.doi.org/10.3389/fnagi.2021.736580

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