Identification of Oleanolic Acid as Allosteric Agonist of Integrin α(M) by Combination of In Silico Modeling and In Vitro Analysis

Oleanolic acid is a widely distributed natural product, which possesses promising antitumor, antiviral, antihyperlipidemic, and anti-inflammatory activities. A heterodimeric complex formed by integrin α(M) (CD11b) and integrin β(2) (CD18) is highly expressed on monocytes and macrophages. In the curr...

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Detalles Bibliográficos
Autores principales: Jin, Lu, Han, Xiaoyu, Zhang, Xinlei, Zhao, Zhimin, Ulrich, Judith, Syrovets, Tatiana, Simmet, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484648/
https://www.ncbi.nlm.nih.gov/pubmed/34603018
http://dx.doi.org/10.3389/fphar.2021.702529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484648/
https://www.ncbi.nlm.nih.gov/pubmed/34603018
http://dx.doi.org/10.3389/fphar.2021.702529

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