SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2

Dysregulation of protein posttranslational modification (PTM) can lead to a variety of pathological processes, such as abnormal sperm development, malignant tumorigenesis, depression, and aging process. SIRT7 is a NAD(+)-dependent protein deacetylase. Besides known deacetylation, SIRT7 may also have...

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Detalles Bibliográficos
Autores principales: Yu, Ai Qing, Wang, Jie, Jiang, Shi Tao, Yuan, Li Qun, Ma, Hai Yan, Hu, Yi Min, Han, Xing Min, Tan, Li Ming, Wang, Zhi Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484718/
https://www.ncbi.nlm.nih.gov/pubmed/34604215
http://dx.doi.org/10.3389/fcell.2021.710479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484718/
https://www.ncbi.nlm.nih.gov/pubmed/34604215
http://dx.doi.org/10.3389/fcell.2021.710479

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