Cargando…

SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2

Dysregulation of protein posttranslational modification (PTM) can lead to a variety of pathological processes, such as abnormal sperm development, malignant tumorigenesis, depression, and aging process. SIRT7 is a NAD(+)-dependent protein deacetylase. Besides known deacetylation, SIRT7 may also have...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Ai Qing, Wang, Jie, Jiang, Shi Tao, Yuan, Li Qun, Ma, Hai Yan, Hu, Yi Min, Han, Xing Min, Tan, Li Ming, Wang, Zhi Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484718/ https://www.ncbi.nlm.nih.gov/pubmed/34604215 http://dx.doi.org/10.3389/fcell.2021.710479

Ejemplares similares

Temporal Dynamic Analysis of Alternative Splicing During Embryonic Development in Zebrafish
por: Liu, Zhe, et al.
Publicado: (2022)

TFP5-Mediated CDK5 Activity Inhibition Improves Diabetic Nephropathy via NGF/Sirt1 Regulating Axis
por: Cao, Shi-Lu, et al.
Publicado: (2022)

PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation
por: Loontiens, Siebe, et al.
Publicado: (2020)

Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation
por: Qian, Zhengyu, et al.
Publicado: (2022)

Targeting alternative splicing in cancer immunotherapy
por: Han, Nan, et al.
Publicado: (2023)

Alternatively Splicing Interactomes Identify Novel Isoform-Specific Partners for NSD2
por: Wang, Weidi, et al.
Publicado: (2021)

Alternative splicing in shaping the molecular landscape of the cochlea
por: Kim, Kwan Soo, et al.
Publicado: (2023)

Histone Demethylase PHF8 Is Required for the Development of the Zebrafish Inner Ear and Posterior Lateral Line
por: He, Jing, et al.
Publicado: (2020)

SYMPK Is Required for Meiosis and Involved in Alternative Splicing in Male Germ Cells
por: Wu, Rui, et al.
Publicado: (2021)

PHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2
por: Chang, Yue, et al.
Publicado: (2021)

Discovery of SIRT7 Inhibitor as New Therapeutic Options Against Liver Cancer
por: Zhang, Chen, et al.
Publicado: (2022)

SIRT7 and hepatic lipid metabolism
por: Tang, Bor Luen
Publicado: (2015)

A novel prognostic 7-methylguanosine signature reflects immune microenvironment and alternative splicing in glioma based on multi-omics analysis
por: Wang, Zihan, et al.
Publicado: (2022)

Polycomb Factor PHF19 Controls Cell Growth and Differentiation Toward Erythroid Pathway in Chronic Myeloid Leukemia Cells
por: García-Montolio, Marc, et al.
Publicado: (2021)

Cleavage and Polyadenylation Specific Factor 1 Promotes Tumor Progression via Alternative Polyadenylation and Splicing in Hepatocellular Carcinoma
por: Chen, Shi-lu, et al.
Publicado: (2021)

The Study of Alternative Splicing Events in Human Induced Pluripotent Stem Cells From a Down's Syndrome Patient
por: Wang, Yunjie, et al.
Publicado: (2021)

Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
por: Dannappel, Marius Volker, et al.
Publicado: (2019)

SIRT6 in Senescence and Aging-Related Cardiovascular Diseases
por: Li, Xiaokang, et al.
Publicado: (2021)

Elevated levels of the methyltransferase SETD2 causes transcription and alternative splicing changes resulting in oncogenic phenotypes
por: Bhattacharya, Saikat, et al.
Publicado: (2022)

Cardioprotective Role of SIRT5 in Response to Acute Ischemia Through a Novel Liver-Cardiac Crosstalk Mechanism
por: Zhou, Boda, et al.
Publicado: (2021)

Mfn2 Overexpression Attenuates Cardio-Cerebrovascular Ischemia–Reperfusion Injury Through Mitochondrial Fusion and Activation of the AMPK/Sirt3 Signaling
por: Liu, Min, et al.
Publicado: (2020)

The Construction of Bone Metastasis-Specific Prognostic Model and Co-expressed Network of Alternative Splicing in Breast Cancer
por: Huang, Runzhi, et al.
Publicado: (2020)

The SIRT1-c-Myc axis in regulation of stem cells
por: Fan, Wei, et al.
Publicado: (2023)

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing
por: Liu, Wenbo, et al.
Publicado: (2022)

Sevoflurane Inhibits Traumatic Brain Injury-Induced Neuron Apoptosis via EZH2-Downregulated KLF4/p38 Axis
por: Wang, Zhongyu, et al.
Publicado: (2021)

The Cyclin B2/CDK1 Complex Conservatively Inhibits Separase Activity in Oocyte Meiosis II
por: Li, Jian, et al.
Publicado: (2021)

Alternative splicing of a single exon causes a major impact on the affinity of Caenorhabditis elegans tropomyosin isoforms for actin filaments
por: Ono, Shoichiro, et al.
Publicado: (2023)

SIRT6 Maintains Redox Homeostasis to Promote Porcine Oocyte Maturation
por: Li, Yu, et al.
Publicado: (2021)

Downregulation of NAGLU in VEC Increases Abnormal Accumulation of Lysosomes and Represents a Predictive Biomarker in Early Atherosclerosis
por: Xing, Changchang, et al.
Publicado: (2022)

CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism
por: Huang, Wen-Li, et al.
Publicado: (2021)

Functional Versatility of the CDK Inhibitor p57(Kip2)
por: Creff, Justine, et al.
Publicado: (2020)

Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria
por: Xu, Huanhuan, et al.
Publicado: (2020)

Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy
por: Wang, Runze, et al.
Publicado: (2021)

Commentary: HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition
por: Baranwal, Somesh
Publicado: (2017)

ERK1/2-EGR1-SRSF10 Axis Mediated Alternative Splicing Plays a Critical Role in Head and Neck Cancer
por: Yadav, Sandhya, et al.
Publicado: (2021)

NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord
por: Leggere, Janelle C, et al.
Publicado: (2016)

Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway
por: Wang, Dong, et al.
Publicado: (2020)

Identification of CDK2-Related Immune Forecast Model and ceRNA in Lung Adenocarcinoma, a Pan-Cancer Analysis
por: Liu, Ting-Ting, et al.
Publicado: (2021)

The many faces of SIRT6 in the retina and retinal pigment epithelium
por: Cheng, Jie, et al.
Publicado: (2023)

The SIRT1-HMGB1 axis: Therapeutic potential to ameliorate inflammatory responses and tumor occurrence
por: Wei, Lanyi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_25qm53fdcd1gp4mhs3n6j000cg