Engineered DNase-inactive Cpf1 variants to improve targeting scope for base editing in E. coli

The development of base editing (BE) technology has opened a new avenue for research studies in bacteriology, particularly for bacterial species in which the DNA double-strand breaks (DSBs) introduced by CRISPR/Cas system would lead to cell death. However, a major limitation of BE-mediated gene edit...

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Detalles Bibliográficos
Autores principales: Chen, Zehua, Sun, Jinyuan, Guan, Ying, Li, Ming, Lou, Chunbo, Wu, Bian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484740/
https://www.ncbi.nlm.nih.gov/pubmed/34632125
http://dx.doi.org/10.1016/j.synbio.2021.09.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484740/
https://www.ncbi.nlm.nih.gov/pubmed/34632125
http://dx.doi.org/10.1016/j.synbio.2021.09.002

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