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Engineered DNase-inactive Cpf1 variants to improve targeting scope for base editing in E. coli
The development of base editing (BE) technology has opened a new avenue for research studies in bacteriology, particularly for bacterial species in which the DNA double-strand breaks (DSBs) introduced by CRISPR/Cas system would lead to cell death. However, a major limitation of BE-mediated gene edit...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
KeAi Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484740/ https://www.ncbi.nlm.nih.gov/pubmed/34632125 http://dx.doi.org/10.1016/j.synbio.2021.09.002 |