In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA

BACKGROUND: Elabela/Toddler (ELA) is a novel endogenous ligand of the apelin receptor, whose signalling has emerged as a therapeutic target, for example, in cardiovascular disease and cancer. Shorter forms of ELA-32 have been predicted, including ELA-21 and ELA-11, but metabolism and stability of EL...

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Detalles Bibliográficos
Autores principales: Nyimanu, Duuamene, Kay, Richard G., Kuc, Rhoda E., Brown, Alastair J.H., Gribble, Fiona M., Maguire, Janet J., Davenport, Anthony P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Inc 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484864/
https://www.ncbi.nlm.nih.gov/pubmed/34455010
http://dx.doi.org/10.1016/j.peptides.2021.170642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484864/
https://www.ncbi.nlm.nih.gov/pubmed/34455010
http://dx.doi.org/10.1016/j.peptides.2021.170642

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