Genome editing of Nf1, Pten, and Trp53 in neonatal mice induces glioblastomas positive for oligodendrocyte lineage transcription factor 2

To generate a mouse glioblastoma model by genome editing, we introduced Cas9 protein and guide RNAs specific for Nf1, Pten, and Trp53 into the neonatal mouse forebrain by electroporation. We found a high incidence (approximately 90%) of glial tumor development, including glioblastomas, 15 weeks late...

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Detalles Bibliográficos
Autores principales: Yamamoto, Hiromi, Yamamura, Keisuke, Nagasaki, Haruka, Suzuki, Takamasa, Ninomiya, Fumiko, Matsubara, Kenji, Harada, Naomoto, Ohkubo, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484922/
https://www.ncbi.nlm.nih.gov/pubmed/34629735
http://dx.doi.org/10.1293/tox.2021-0029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484922/
https://www.ncbi.nlm.nih.gov/pubmed/34629735
http://dx.doi.org/10.1293/tox.2021-0029

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