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Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)
The constitutive androstane receptor (CAR)-mediated mode of action (MOA) for phenobarbital (PB)-induced rodent liver tumor formation has been established, with increased hepatocyte proliferation, which is a key event in tumor formation. Previous studies have demonstrated that PB and other CAR-activa...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Japanese Society of Toxicologic Pathology
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484926/ https://www.ncbi.nlm.nih.gov/pubmed/34629731 http://dx.doi.org/10.1293/tox.2021-0027 |