Novel Escherichia coli active site dnaE alleles with altered base and sugar selectivity

The Escherichia coli dnaE gene encodes the α‐catalytic subunit (pol IIIα) of DNA polymerase III, the cell’s main replicase. Like all high‐fidelity DNA polymerases, pol III possesses stringent base and sugar discrimination. The latter is mediated by a so‐called “steric gate” residue in the active sit...

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Detalles Bibliográficos
Autores principales: Vaisman, Alexandra, Łazowski, Krystian, Reijns, Martin A. M., Walsh, Erin, McDonald, John P., Moreno, Kristiniana C., Quiros, Dominic R., Schmidt, Marlen, Kranz, Harald, Yang, Wei, Makiela‐Dzbenska, Karolina, Woodgate, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485763/
https://www.ncbi.nlm.nih.gov/pubmed/34181784
http://dx.doi.org/10.1111/mmi.14779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485763/
https://www.ncbi.nlm.nih.gov/pubmed/34181784
http://dx.doi.org/10.1111/mmi.14779

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