Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress

While phosphatidylinositide 3-kinase delta (PI3Kδ) plays a critical role in humoral immunity, the requirement for PI3Kδ signaling in plasma cells remains poorly understood. Here, we used a conditional mouse model of activated PI3Kδ syndrome (APDS), to interrogate the function of PI3Kδ in plasma cell...

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Detalles Bibliográficos
Autores principales: Al Qureshah, Fahd, Sagadiev, Sara, Thouvenel, Christopher D., Liu, Shuozhi, Hua, Zhaolin, Hou, Baidong, Acharya, Mridu, James, Richard G., Rawlings, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485856/
https://www.ncbi.nlm.nih.gov/pubmed/34586341
http://dx.doi.org/10.1084/jem.20211035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485856/
https://www.ncbi.nlm.nih.gov/pubmed/34586341
http://dx.doi.org/10.1084/jem.20211035

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