MicroRNA-directed pathway discovery elucidates an miR-221/222–mediated regulatory circuit in class switch recombination

MicroRNAs (miRNAs, miRs) regulate cell fate decisions by post-transcriptionally tuning networks of mRNA targets. We used miRNA-directed pathway discovery to reveal a regulatory circuit that influences Ig class switch recombination (CSR). We developed a system to deplete mature, activated B cells of...

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Detalles Bibliográficos
Autores principales: Wigton, Eric J., Mikami, Yohei, McMonigle, Ryan J., Castellanos, Carlos A., Wade-Vallance, Adam K., Zhou, Simon K., Kageyama, Robin, Litterman, Adam, Roy, Suparna, Kitamura, Daisuke, Dykhuizen, Emily C., Allen, Christopher D.C., Hu, Hui, O’Shea, John J., Ansel, K. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485858/
https://www.ncbi.nlm.nih.gov/pubmed/34586363
http://dx.doi.org/10.1084/jem.20201422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485858/
https://www.ncbi.nlm.nih.gov/pubmed/34586363
http://dx.doi.org/10.1084/jem.20201422

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