S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

SARS-CoV-2 virions are surrounded by a lipid bilayer that contains membrane proteins such as spike, responsible for target-cell binding and virus fusion. We found that during SARS-CoV-2 infection, spike becomes lipid modified, through the sequential action of the S-acyltransferases ZDHHC20 and 9. Pa...

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Detalles Bibliográficos
Autores principales: Mesquita, Francisco S., Abrami, Laurence, Sergeeva, Oksana, Turelli, Priscilla, Qing, Enya, Kunz, Béatrice, Raclot, Charlène, Paz Montoya, Jonathan, Abriata, Luciano A., Gallagher, Tom, Dal Peraro, Matteo, Trono, Didier, D’Angelo, Giovanni, van der Goot, F. Gisou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486083/
https://www.ncbi.nlm.nih.gov/pubmed/34599882
http://dx.doi.org/10.1016/j.devcel.2021.09.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486083/
https://www.ncbi.nlm.nih.gov/pubmed/34599882
http://dx.doi.org/10.1016/j.devcel.2021.09.016

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